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posted by [personal profile] malnpudl at 12:06am on 02/05/2012
Decisions, they are hard.

TL;DR version: Since I went back on antidepressant meds four years ago, I've almost entirely stopped writing fic. I miss it dreadfully, enough that I'm considering switching to a different, less effective drug to see if that would help.

So the thing is that I'm a lifelong depressive; my neurochemistry has been out of whack pretty much from the very beginning, as far as I and a whole bunch of people with letters after their names can tell, though I didn't get a formal diagnosis or meds for it until my late twenties. (Much, much too long.)

For thirteen pretty good years I took a tricyclic (read: old) antidepressant called imipramine (Tofranil) and it worked pretty well. I went from invariably using my maximum allowed twelve sick days per year, putting me in constant danger of disciplinary action or even job loss, down to two or three – which is to say, when I stayed home sick, it was with a virus, not sick with depression (which is not something one could sell to any boss I've ever had, physiological reality notwithstanding). I still felt like me. I still had all my emotions; I just didn't get stuck in the downswings. I was no longer immobilized by the paralysis of will that is far and away the worst thing about this damned condition.

Then, due to a combination of deeply fucked up circumstances that aren't worth rehashing, mishandling of a stupidly mandated med switch further fucked up my neurochemistry and neither the new drug nor my old faithful meds worked very well. Additionally, they started causing some wretched side effects, the worst of which – and you have no idea unless you've lived through it – is drenching me in free-flowing rivers of sweat much of the time, regardless of temperature or circumstances. It's not just unpleasant, it's hell.

In hopes of finding a better solution, I got referred to an awesome psychiatrist who patiently worked with me for three and a half years trying to find a medication that would help with my depression and not cause the same or worse side effects. I tend to have atypical reactions to these meds (Prozac, for example, made me sleep all the time, a very rare but documented side effect). We went through a round dozen meds before he finally ran out of options.

This was pretty much simultaneous with my relocation from the Bay Area to the north coast of California where I live now, so I made the decision to go off all psych meds after the move (in a supervised dosage phase down, of course).

I lived off meds for several years and for the most part was okay with it. I was not as functional as I would've been on meds, but I didn't have to live with the hellish side effects, and that was great. Also, after going on and off so many mess-with-your-brain drugs over such a long time, it was really good to return to just being myself; it was wonderfully refreshing, almost a rediscovery, not to mention a relief. By that time I'd been granted permanently disabled status and started receiving SSDI (US federal disability payments) so I didn't have to worry about fiscal survival. It wasn't a lot of money, but I could manage.

It was during that time that I found fanfic and fandom, and shortly after that I started writing, which was a tremendously joyous thing.

Unfortunately I found myself in a major downswing about four years ago that went on and on and on for months, and it just kept getting worse.

Sidebar: One of the best measures I've found for exactly how depressed I am is how often I have suicidal thoughts, and how intense they are.

This is something nobody ever told me about when I was diagnosed with depression, and I really wish they had: Suicidal ideation isn't just a symptom of depression; it's a product of depression.

I remember the first time I was aware of thinking of suicide. It was so utterly foreign to my nature that I was startled by it – where the hell did that come from? One thing I'd learned about myself over many long years and many hard times is that I'm a survivor. I can and will survive pretty much anything I'm faced with. I may not do it well, I may fail at coping, but by damn I will survive. It wasn't even a question.

There's nothing like being severely neurochemically depressed as a baseline state and then going on and off a bunch of antidepressant meds to drive home how suicidal ideation works. Off meds, there'd be a constant flow of such thoughts. They even felt rational at the time – though fortunately I always knew better than to let those emotions overrule my rational understanding that they were irrational and, in fact, artificial thoughts. On meds, not only did those suicidal thoughts go away, but all of the life-and-circumstance challenges that felt so hopeless and overwhelming while off meds became things I knew with certainty that I could deal with. Off meds, the suicidal ideation comes back; back on the next drug, it goes away.

Back to the story: So about four years ago, the flow of suicidal thoughts swelled to a tidal wave, an overwhelming inundation. It took everything I had just to keep pushing them back. I was never in any danger of taking action – I know better than that; I'm too well-informed and self-aware about this – but it became very clear that I was headed in a dangerous direction and if I continued uninterrupted on the same path without taking some action, I could end up in a crisis that would require dramatic intervention, like hospitalization.

So I went to the doctor and got back on imipramine, my old faithful first medication, and ever since then I've been pleased to be more functional; unhappy to be wretchedly, hellishly drenched in sweat much of the time (it'd be nice to be able to wear dry underthings like, ever, really it would); constantly struggling to fight the sedation and pump enough caffeine into myself to just wake the fuck up; enjoying a modest but significant degree of general pain relief; and the suicidal thoughts are so mild, occasional, and fleeting that they're effortlessly dismissed.

But. BUT. I have almost entirely stopped writing since going back on meds. I've managed it a few times, yeah, but it takes extreme effort to get it started and the pressure of a looming and non-negotiable deadline.

I miss it dreadfully. I don't even have words for how much I miss it. It's like an amputation. I feel a constant sense of loss.

A year ago, pondering all this, I was all set to go off my antidepressant and try SAM-e instead since it has antidepressant (and other) benefits and is activating rather than sedating. Great plan... except that I got surprised with the diabetes diagnosis, for which I take metformin, which does not play well with SAM-e. Well, hell. Given that my sugars had reached scary high levels (close to 400) by the time I was diagnosed, the one and only priority was getting that under control. Which I have since done; that's doing pretty nicely now. The diabetes will never go away, but the numbers are staying where they belong and I know how to keep them that way.

Which brings us to now.

I want to write again without it being a constant, huge struggle. I want it so badly it's a physical ache.

So my latest thought is to go off my old faithful antidepressant and instead go on Wellbutrin (bupropion). I've tried it in the past; it was one of the dozen.

The upside is that it's not sedating (possibly even activating), it didn't cause the extreme sweating (some, but not nearly so much), it helps with pain in the same way as my current meds, it didn't shut down my libido, and it dramatically reduced my cravings, which in me are expressed in eating and particularly over-eating for a hundred reasons that have nothing to do with hunger. Taking it would make it even easier to stay on healthy diabetic eating and make it far more likely that I would also drop some weight, slowly and over time but eventually significant, which would ease the stress on my train-wreck knees and crappy hip joints.

The downside... it was one of the less effective meds I've tried in terms of treating the actual depression. It helped, but not as much as some of the others.

Yeah. I know.

Still, it feels like it's worth a try. It's always a trade-off with me. It's always going to be a world of compromises, whole stacks of them, and all I can do is balance them off against each other.

I think I may be ready to swing the neurochemical pendulum in the other direction for a while and see what happens. No guarantee that it would free up the creative brain and get me writing again... but it seems like a more sensible approach than going off meds altogether.

Worth a try? Maybe?

Comments and thoughts are entirely welcome, should anyone care to offer them, and actively solicited if any part of this happens to resonate with any of your own experiences. Anonymous commenting is allowed; IP logging is turned off.
There are 10 comments on this entry. (Reply.)
blueraccoon: bitmoji avatar of me, a white woman wearing red glasses with a pink buzzcut (Default)
posted by [personal profile] blueraccoon at 07:19am on 02/05/2012
So, I've had this problem before. Somewhat ironically, it happened to me with Wellbutrin.

I was in the middle of my "lost year", and I started seeing a new psychiatrist. The Zoloft I'd been taking until that point wasn't working anymore, and so we tried something new, the Wellbutrin (whcih at that point wasn't a generic, iirc). I hated it. First I felt like I had a caffeine IV in me for a week. Then that wore off, but I couldn't write a word. I felt like my words, my stories, were trapped behind a glass wall in my mind. I could see them, I could almost read them, but I couldn't get to them.

I hated this so badly I took myself off the Wellbutrin. Writing, at that point, was the only coping mechanism I had. I wasn't in school, I wasn't working, I wasn't really doing anything except writing, and without that, I had nothing. My psychiatrist at the time wasn't helpful; she said "But you're not as depressed!" I said "But I CAN'T WRITE". She said "But it's helping your depression!" I said "BUT I CAN"T WRITE" and stopped taking it.

What eventually saved me was a combination of things, but these days I have more luck with mood stabilizers and atypical antipsychotics than with anti-depressants. I do take all three; I take lamotrigine (mood stabilizer), risperidone (atypical antipyschotic) and venlafaxine (SNRI, or something like that). I have no idea what your meds history is, what you have or haven't tried, but perhaps something like lamotrigine could work for you? My problems are more with anxiety than with depression, although they both get me if I'm not careful. I'm more aware of the anxiety, which means the depression sneaks up on me and I don't always realize it's there. But as soon as I stop being able to write, I know something's out of whack.

I wish you luck; I really, really do. I've also done a meds merry-go-round and tried just about everything, which leaves me nervous for if/when my current cocktail stops working. So if you want to talk, let me know. I hop this helps at least a little, at least to let you know you're not alone.
dodificus: (Default)
posted by [personal profile] dodificus at 07:32am on 02/05/2012
Suicidal ideation was such a regular part of my 'life with depression' (something that spanned over a decade) that it's been something of a revelation to live *without* it these last couple of years. I honestly never thought I'd reach this point and it continues to shock and awe me that I have.

I wish you the best with whatever choice you go with:)
 
posted by [personal profile] secondalto at 12:03pm on 02/05/2012
I was diagnosed as bi-polar after the birth of my son. At first they put me on Lithium, but I had the unfortunate side-effect of puking my guts out. They told me to stay on it for a week, it would go away, but after three days I said ENOUGH. They changed me to Depakote. Looking back, I'm not sure it worked. I still had mood swings, but they weren't as dramatic as they had been, so maybe it did something. Unfortunately because I'm on Medicaid there was only one place I could go to for psychiatric help and they had a rotating cadre of doctors. One of them added Paxil to my regimen for anxiety. But when I got a job and started making too much money to qualify for Medicaid, I went off all medication. That was around 2004. I've been off ever since.

I still get mood swings and yes they can be dramatic. But I've noticed that my suicidal thoughts are practically non-exisitant. I attribute that to my kids and to finding fandom. I think finally finding a place where I belong had helped enormously. And I'm okay with my mood swings. I write in both manic and depressive phases, they just effect what kind of things I write.

So all in all, I think I would prefer to stay off meds, I like it that way.
etcetera_cat: (Default)
posted by [personal profile] etcetera_cat at 06:58pm on 02/05/2012
Okay so, firstly: ALL THE HUGS FOR YOU. I've been in the place where medication takes away your writing, and it is both deeply unpleasant and oft-times frustrating to explain to the doctor that yes, maybe you aren't showing typical depressive signs, but the inability to write means that you spend a hella lot of time only juuuust this side of okay.

(I...okay, so currently I am not writing, despite having been off meds entirely since around February of this year, but I am having ideas and creative thoughts again, which i didn't realised I missed until I got them back)

...this is going slightly out of step, isn't it? Sorry. So, you probably know--because I'm not exactly backwards about it--that I have bipolar disorder (currently we're calling it atypical type one, but that is, as always, subject to change), which I was diagnosed with about 6 years ago now. I am currently off all medication, and will probably not ever be able to take medication, as I have hilarious and comedic rare side-effects to (now) everything, which run the gamut from being unable to eat due to throwing up all the time, to auto-immune disease and a few instances of my kidneys saying "...you know what? Screw you, bitch!"

With actual anti-depressants on board, my depressive phases were filled in, but my utter lack of creativity (or sometimes, consciousness period) were as debilitating as the actual depression, which is one of the (non-my-body-is-a-spanner) reasons I got switched onto mood stabilisers instead. The one I took the longest was lamotrigene (which is primarily and originally an anti-epilepsy med that's supposed to be non-sedative), which dulled my creativity a bit, but I could (and did!) write on it. I did stop taking it from side-effects (massive auto-immune skin reaction), but those side effects are RARE and I am absolutely NOT a benchmark for the likelihood of a side effect occuring.

...In some cases I am the only documented case of said side effect. Like the time a mood stabiliser gave me synaesthesia and a concommitant "allergy" to the colour blue (if I saw something blue, I sneezed uncontrollably) /o\

wrt to the suicidal ideation: boy howdy do I know where you're coming from there, and I'm so glad that you're able to recognise that behaviour as abherrant. Is there any kind of mental health crisis outreach set up in your area? The local mental health centre to me (well, before it closed) used to run these sort of open-house/coffee morning things where you could go if you were hitting that kind of spiral down, but you didn't actually have to talk to anyone if you didn't want to, but sometimes just the act of being somewhere else and doing something routine was enough to break the bad thoughts.

And, okay, so sometimes it isn't. And hospitalisation/medical eval seems really fucking scary from the outside (and, okay, yeah, it is), but it's not necessarily bad. And you do come out the other side of it. (I have. More than once).

&you;
 
posted by [personal profile] pudacat at 08:53pm on 02/05/2012
In my mid-twenties, I read a book wherein the author mentioned tht she had gone on Prozac, and lost all her poetry. When she mentioned it to her doctor, he dismissed it, telling her it was an unspoken side-effect, but she should be happy she wasn't biologically depressed. She went off it, and her muse returned. Less that 5 years later, I was put on Effexor XR, and thoroughly lost the ability to tell myself stories, something I had done my whole life. (Literally. I shipped Gilligan and Mary Ann at age 4.) I GOT what she meant. 14 years later, (age:44) I still have no regrets. Sometimes the ability to storytell comes back, and I'm guaranteed a depressive episode within a month, requiring my dosage to be upped. Fortunately, I'm not a writer, and it doesn't interfer with the pleasure I get out of reading. So I read instead. Nights are bad because I have insomnia, and always have. I had always used the storytelling to put myself to sleep, but that's the only regret. If I lost the pleasure I get in reading, I would quit in a heartbeat. I can't imagine what you're going through, but, I know for myself, I would choose to be dysthemic and able to pursue what I love, than be "normal", and constantly ache for what I lost. If Wellbutrin could put you at that point, it might be worth considering. I am biased, however. I love your SGA fanfic, and have no idea what your life is like. Asking around, which included both my doctor and therapist, it seems like what you're going through is common for creative types. It's just considered worth losing. While I don't want to agree, reading Eliade's Livejournal is a study in heartbreak. My 2 cents. (Uni-polar depressive since puberty,-31 years-finally held in check since age 30, but not at the cost you.ve paid.)
mific: (Default)
posted by [personal profile] mific at 01:50am on 03/05/2012
Damn - it's a real dilemma for you, trying to find some way through all that. Look, this is probably useless and redundant, but have you tried a MAOI antidepressant? I'm sure you have but I'm mentioning it as the MAOIs are sometimes these days seen as "older fashioned" options, however for many people they work really well. There are some major dietary restrictions with them and a few significant interactions with other meds that have to be managed, but they don't clash with diabetes that I'm aware, and they cause less weight-gain, usually. However I'm sure you tried one at some point there, but just thought I'd mention it.
And this won't be popular but I have a good friend in her forties with recurrent and intractable depression for whom none of the meds work, and the only thing that works for her is maintenance ECT. She goes in and has it as an out patient once a fortnight, sometimes only once a month, and it keeps her well. But I realise that'd be a big step.
I know I'm only talking about biological treatments here, but I'm sure you've tried all the usual therapy things and you seem to be presenting the biologically-driven aspects of your depression in particular.
Good luck in trying to find a solution, anyway.
hazelwho: (coffee zombie)
posted by [personal profile] hazelwho at 11:45pm on 03/05/2012
I was just talking with my best friend this weekend about this. She's been on scary-high doses of antidepressants for years, because after trying them all they found only super-high doses do anything for her. But recently, she missed a dose, then another, then another. And then she started feeling everything again and had a, "holy shit, it's been YEARS" freakout. She was okay for a while, but then she started doing her usual worsening-depression stuff like social withdrawal, waking up at 2am, crying a lot, ruminating on family stuff, torturing herself about her breakup with her husband, and even having passive suicidal thoughts ("it would be so much better if i just didn't wake up and have to deal with this shit anymore"). Now that she's off, she doesn't want to go back on. But as someone who's known her forever and loves her to bits, I can tell a huge difference and I think she was happier and healthier before. She said she was going to go see a doc about a differnt kind of med this week, one that won't make her so numb.

I've been pretty lucky myself. Lexapro worked well for me for years, and then I was fine off meds for years, and now I've been doing well on Zoloft for the last three years. But I know med selection can be really tricky. Some things just plain don't work for some people. If you had a lot of luck with Imiprimine (except for the side effects), then it stands to reason that a combination of serotonin and norepinephrine effects would work well for you. The SSRIs (zoloft, prozac, etc) mostly work on serotonin receptors. Buproprion works on serotonin and dopamine receptors. There is a class of drugs called SNRIs (Effexor, Cymbalta) that are new like the SSRIs and work on serotonin and norepinephrine receptors just like the old TCAs, but with fewer side effects. It might be worth asking your doc about trying one of those?
luzula: a Luzula pilosa, or hairy wood-rush (Default)
posted by [personal profile] luzula at 08:37am on 04/05/2012
I really have no experience to offer, except possibly that for my mom it worked to go down in dosage until she hit a good trade-off point between the drug's action and its side-effects (she's on Cipramil). But anyway, I am so impressed by your self-awareness about all this, and I wish you all the luck in finding a trade-off that works for you. I'll be thinking of you. *all the hugs*
woolly_socks: me with red hair, and fishnet sleeves, hand over face (Default)
posted by [personal profile] woolly_socks at 11:34pm on 06/05/2012
It's always really sobering to read someone's history with depression and meds written out like this. I'm sure that mine isn't a cheerful read either. I've been medicated since I was a teenager, with a break in there after a really bad experience with being accidentally given antipyschotics instead of antidepressants. /o\

I'm not sure if I have any useful thoughts except to say that I know from experience that it takes a ton of courage to live with this sort of stuff, and keep getting out of bed in the morning. You have my deepest admiration and respect. To me, this (sort of thing) is what real strength and courage are.

I'm currently trying to get off all meds, because I'm convinced that they are interfering with my recovery from CFS. My depression has long been in remission, although I am still highly sensitive, physically and emotionally.

I know people who are off meds altogether because the side effects are not worth the benefits. It's not easy to live with no chemical support for chronic depression, but for some the way it messes with their brain and body chemistry is just not worth it.

Maybe it's just a case of finding a balance? How do you do on low dosages? I guess it's pointless if you just end up with the worst of both sides instead of the best.

<3
bonspiel: (Default)
posted by [personal profile] bonspiel at 01:05am on 10/05/2012
Wellbutrin is the only antidepressant I've been on long-term. I've been told that its withdrawal effects/process is much less fraught than most antidepressants, so that might suggest it might be worth a try. Not like my friend who wanted to have a baby and had to taper off her meds for a *year*. I found that its effects on my creativity were mixed.

The two meds I tried before Wellbutrin made me stupid happy - which would have been a problem if it had continued because my inhibition was way too low. Part of that was the giddy glee I was feeling at having any feelings at all, after a couple of years of pure anhedonia. When I switched to Wellbutrin it was much less mania-inducing, and it helped me a lot with my slow healing process from my worst depressive episode. There were times, looking back, that I was a little flatter than my best self, my most creative self, would have been, but at that point I took the tradeoff because I was able to think and have friends and care about things again.

When I went off it was rather unplanned - a switch to the generic version (due to insurance bullshit) gave me tachycardia, and so I had to go off it pretty quickly. I didn't have any serious problems, but I was also distracted by trying to make sure that my heart wasn't going to explode - heart rate of 150 plus while sitting calmly in a chair is fun, let me tell you. Once I was off it I did feel more creative, did more creative stuff, but was also more volatile. It was almost like the meds raised up the lows but also flattened out the highs.

It's been 2+ years now, I think, and so far I've been able to manage without going back on any meds. I think I'm probably dysthymic, with occasional overlapping major depression, and so far I've been able to manage with non-med interventions like meditation and exercise and managing stress, but I don't have a regular job so that makes it much easier. I'm kinda waiting for the other shoe to drop, because I still struggle at times - I think the worst effect for me is not always having the confidence to follow through with my ideas, to think that they have merit or that anyone else will find them interesting.

But if you feel stuck at the stage where you don't have any ideas at all, or it doesn't feel like it, then I do think that's worth monkeying with your meds for, even if the doc isn't as convinced.

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